This article examines the legal frameworks that shape the circulation and governance of information in the International Amazon, emphasizing the need to build informational sovereignty grounded in the forest territories. The research compares Brazil and Colombia through a qualitative and documentary approach, analyzing legislation, reports, and multilateral agreements within the project “Communication Studies for Regional and Environmental Development.” The study proposes the concept of Sensitive Regulation, linking information ethics, communication rights, and epistemic diversity. The findings reveal that data capitalism imposes new ethical and political dilemmas on Amazonian communication, demanding regulatory frameworks capable of recognizing the region’s cultural and territorial plurality and strengthening alternative journalism and informational resistance.