This paper discusses how technological production has been suffering effects of international transformations in terms of institutional reorganization of research centers. Technicians and scientists had their activities redefined from new organizational formats that are established nowadays. The globalization and internationalization of the scientific field represent tendencies that have affected the constitution of social groups that lead technological practice worldwide. Today it is possible to detect articulation of global processes of companies, laboratories and public research institutions by creating science and technology while uprooted and asymmetric. The questions posed to developing countries is how internationalization of scientific research has been impacting national institutions; and how have national scientific elites been behaving before the new parameters of technological research funding. The aim of this text is to verify how these tendencies have been impacting the scientific and technological production of the Public Research Institute. To elucidate these questions we analyze the case of the Technological Research Institute (Instituto de Pesquisas Tecnológicas - IPT) that is embedded in USP and linked to the Development, Economy, Science and Technology Secretariat of São Paulo State.