This article defends the idea of a Cultural Political Economy – CPE, exploring the constitutive role of semiotics in economic and political activities and in the social order in general. This approach is post-disciplinary: it adopts the "cultural turn" in economic and political research, while not ignoring the articulation between semiotics and the interconnected materialities in economics and politics, within broader social formations. This approach is illustrated in the Knowledge-Based Economy – KBE as a master-discourse in accumulation strategies at different scales, state projects and hegemonic views, and diverse functional systems and professions, as well as in civil society.