We live in the age of a labs revolution. The emergence of laboratories, as spaces for experimentation and collaborative and experimental production, opens the discussion about how we approach social complexity. In this paper we seek to discuss their possibilities as a common framework, model, prototype, practice, or methodology to rethink the university as an institution and the field of digital humanities. We deem it necessary to have a deeper dialogue with initiatives related to open and citizen science, distributed learning and open data, closer to social movements than to academic culture. We reflect on the possibilities of incorporating the lab culture to promote, disseminate, document, and facilitate processes of open knowledge production in Iberoamerica, which becomes an opportunity for both social and institutional transformation.